TABLE 1

Tumor Growth (TG) in Normoxic and Hypoxic Tumors

		TG: 70- to 500-μL volume		aGD		log cell kill
Treatment group	n	Days	P	Days	P		P
Normoxic tumors
CHT (TPZ)	7	13.3 ± 1.6		−2.3 ± 1.6		−0.11 ± 0.09
RT (radiation)	10	22.3 ± 1.3	<0.01^*	6.7 ± 1.3	<0.001^*	0.34 ± 0.08	<0.02^*
RCT (radiation + TPZ)	8	21.6 ± 1.6	<0.02^*	6.0 ± 1.6	<0.02^*	0.38 ± 0.09	<0.02^*
Control (sham treatment)	9	15.6 ± 1.4		0.0 ± 1.4		0.0 ± 0.09
Hypoxic tumors
CHT (TPZ)	9	14.3 ± 1.4		3.3 ± 1.4	<0.02^†	0.25 ± 0.08	<0.05^*, <0.01^†
RT (radiation)	7	18.6 ± 1.6	<0.01^*	7.6 ± 1.6	<0.01^*	0.60 ± 0.1	<0.001^*
RCT (radiation + TPZ)	8	23.9 ± 1.5	<0.001^*	12.9 ± 1.5	<0.01^*, <0.05^†	0.88 ± 0.1	<0.001^*, <0.01^†
Control (sham treatment	9	11.0 ± 1.4	<0.02^†	0.0 ± 1.4		0.0 ± 0.08

↵* Significant difference between treatment and control (within groups).
↵† Significant difference between hypoxic and normoxic groups.
Data are presented as mean ± SE.