Correlation Between Rate Constants and Lactate Metabolism
| Lactate uptake | 11C-Lactate uptake | PR(11CO2)LA rate | ||||
|---|---|---|---|---|---|---|
| mL/g/min | ||||||
| Rate constant | R | P | R | P | R | P |
| k1B (min−1) | NS | NS | −0.59 | <0.005 | ||
| k2B (min−1) | NS | +0.44 | <0.05 | +0.41 | 0.06 | |
| k3B (min−1) | NS | NS | NS | |||
| k4B (min−1) | NS | NS | NS | |||
| K5B (mL/g/min) | NS | +0.58 | <0.005 | NS | ||
| k6B (min−1) | NS | +0.65 | <0.001 | +0.45 | <0.05 | |
| k7B (min−1) | NS | +0.61 | <0.005 | +0.43 | <0.05 | |
k1B–k6B = estimated rate constants; lactate uptake = lactate extraction fraction × MBF; 11C-lactate uptake = 11C-lactate extraction fraction × MBF; PR(11CO2)LA rate = fractional 11CO2 production from 11C-lactate × MBF; R = correlation coefficient; NS = not significant.