TABLE 1

18F-FDG Kinetics Estimated by 3-Compartment Model and Patlak Analysis, Respectively

Mouse
Parameter1234
Brain
Embedded Image (mL/min/g)0.130.080.090.10
Embedded Image (min−1)0.290.080.260.21
Embedded Image (min−1)0.070.030.040.05
Embedded Image (min−1)0.0210.0100.0110.019
Embedded Image (mL/min/g) by 18F-FDG model0.0250.0180.0140.018
Embedded Image (mL/min/g) by Patlak analysis0.0230.0180.0140.016
Myocardium
Embedded Image (mL/min/g)0.360.090.070.07
Embedded Image (min−1)0.220.070.050.13
Embedded Image (min−1)0.160.030.030.10
Embedded Image (min−1)0.00463.95E−061.63E−050.0006
Embedded Image (mL/min/g) by 18F-FDG model0.1490.0250.0240.029
Embedded Image (mL/min/g) by Patlak analysis0.1400.0230.0270.029
  • Tissue data of 3−22 min were used to minimize effect of significant Embedded Image value.

  • Tissue data of 3−55 min were used because of negligible Embedded Image value.