TABLE 3

Serum Tg Levels in Children and Adolescents with DTC

Time of Tg evaluation^*			Hormonal status	Detectable Tg^† (>1 ng/mL)	Median (range in ng/mL)
Before adjuvant ¹³¹I therapy		Off T₄ therapy (n = 107)	72 (67)	3.5 (0.2–320)	}0.01
At diagnosis of LR		Off T₄ therapy (n = 17)	17 (100)	26.3 (1.1–581)	}0.01
		On T₄ therapy (n = 6)	2 (33)	0.6 (0.2–43)
At last follow-up (on T₄ therapy)	Children with recurrence during follow-up	On T₄ therapy (n = 30)	1 (3)	0.4 (0.2–1.7)	}NS
	Children without recurrence during follow-up	On T₄ therapy (n = 130)	5 (4)	0.3 (0.2–6.5)	}NS

↵* Only cases with Tg recovery > 75% were included; children who had distant metastases were excluded.
↵† Values in parentheses are percentages.
NS = not significant.