Patient Characteristics and Organ Involvement
| Parameter | Control | AA | AL | ATTR | Localized amyloidosis |
|---|---|---|---|---|---|
| Number of patients | 20 | 60 | 80 | 27 | 22 |
| Male:female | 14:6 | 19:41 | 46:34 | 13:14 | 12:10 |
| Age (y) | 53.3 (17.0) | 56.5 (14.7) | 61.8 (10.2) | 51.8 (10.5) | 50.6 (12.1) |
| I. Heart | |||||
| a. Mean thickness* > 12 mm | 1 (5%) | 7 (12%) | 36 (45%) | 9 (33%) | 0 (0%) |
| b. Heart failure† | 1 (5%) | 3 (5%) | 24 (30%) | 2 (7%) | 0 (0%) |
| c. Low-voltage electrocardiography | 0 (0%) | 4 (7%) | 23 (29%) | 1 (4%) | 0 (0%) |
| Heart involvement (a, b, or c) | 2 (10%) | 11 (18%) | 44 (55%) | 9 (33%) | 0 (0%) |
| II. Kidney | |||||
| d. Proteinuria > 0.5 g/24 h | 8 (40%) | 39 (65%) | 51 (64%) | 1 (4%) | 0 (0%) |
| e. Creatinine clearance < 60 mL/min | 10 (50%) | 41 (68%) | 38 (48%) | 3 (11%) | 1 (5%) |
| Kidney involvement (d or e) | 11 (55%) | 54 (90%) | 66 (83%) | 4 (15%) | 1 (5%) |
| III. Liver | |||||
| f. Liver span > 16 cm | 0 (0%) | 0 (0%) | 15 (19%) | 0 (0%) | 0 (0%) |
| g. Alkaline phosphatase > 180 kU/L | 0 (0%) | 3 (5%) | 18 (23%) | 0 (0%) | 0 (0%) |
| Liver involvement (f or g) | 0 (0%) | 3 (5%) | 24 (30%) | 0 (0%) | 0 (0%) |
| IV. Nervous tissue | |||||
| h. Peripheral polyneuropathy | 2 (10%) | 2 (3%) | 26 (33%) | 21 (78%) | 1 (5%) |
| i. Autonomic neuropathy | 1 (5%) | 7 (12%) | 33 (41%) | 20 (74%) | 1 (5%) |
| Nerve involvement (h or i) | 2 (10%) | 8 (13%) | 40 (50%) | 23 (85%) | 1 (5%) |
| Number of organs involved: | |||||
| 0 | 6 (30%) | 4 (7%) | 2 (3%) | 2 (7%) | 20 (91%) |
| 1 | 12 (60%) | 41 (68%) | 20 (25%) | 15 (56%) | 2 (9%) |
| 2 | 2 (10%) | 10 (17%) | 27 (34%) | 9 (33%) | 0 (0%) |
| 3 | 0 (0%) | 5 (8%) | 24 (30%) | 1 (4%) | 0 (0%) |
| 4 | 0 (0%) | 0 (0%) | 7 (9%) | 0 (0%) | 0 (0%) |