TABLE 1

GLP-1 Receptor Incidence and Density in Human Tumors

Tumor typeGLP-1 receptor incidence*GLP-1 receptor density†
Endocrine tumors
 Pheochromocytomas12/20 (60)3,970 ± 1,002
 Paragangliomas5/18 (28)1,353 ± 601
 Medullary thyroid carcinomas5/18 (28)1,326 ± 264
 Adrenal cortical adenomas0/7 (0)
 Parathyroid carcinomas0/4 (0)
 Pituitary adenomas0/38 (0)
Tumors of nervous system
 Meningiomas7/20 (35)989 ± 271
 Astrocytomas4/16 (25)1,069 ± 398
 Glioblastomas2/21 (9)790 ± 120
 Ependymomas1/6 (16)1,075
 Schwannomas0/9 (0)
Embryonic tumors
 Medulloblastomas3/12 (25)1,246 ± 726
 Nephroblastomas2/9 (22)421 ± 21
 Neuroblastomas3/16 (18)932 ± 518
Carcinomas
 Ovarian adenocarcinomas2/12 (16)688 ± 384
 Prostate carcinomas1/20 (5)1,283
 Breast carcinomas0/22 (0)
 Colorectal adenocarcinomas0/21 (0)
 Gastric adenocarcinomas0/20 (0)
 Pancreatic adenocarcinomas0/21 (0)
 Cholangiocellular carcinomas0/17 (0)
 Hepatocellular carciomas0/16 (0)
 Non–small cell lung carcinomas0/20 (0)
 Small cell lung carcinomas0/6 (0)
 Renal cell carcinomas0/20 (0)
Non–Hodgkin's lymphomas0/10 (0)

  • ↵* Values in parentheses are percentages.

  • ↵† Mean ± SEM of receptor-positive cases (dpm/mg tissue).