Diagnostic Characteristics of Cutoff Values
| Outcome parameter | Liver failure | Liver failure–related mortality |
|---|---|---|
| Cutoff value | 2.5%/min/BSA | 2.2%/min/BSA |
| Sensitivity | 83% | 75% |
| Specificity | 90% | 93% |
| PPV | 56% | 50% |
| NPV | 97% | 98% |
| LR+ | 8.3 (2.8–100) | 11 (2.2–∞) |
| LR− | 0.2 (0–0.6) | 0.3 (0–0.8) |
| Prevalence | 13% | 9% |
| Posttest chance+ | 56% (30%–94%) | 50% (17%–100%) |
| Posttest chance− | 3% (0%–8%) | 3% (0%–7%) |
| + | − | + | − | |||
|---|---|---|---|---|---|---|
| <cutoff value | + | 5 | 4 | + | 3 | 3 |
| >cutoff value | − | 1 | 36 | − | 1 | 39 |
PPV = positive predictive value; NPV = negative predictive value; posttest chance+ = posttest chance when test is positive; posttest chance− = posttest chance when test is negative.
Data in parentheses are 95% confidence intervals. Tests were considered positive when below cutoff value. 2 × 2 tables are shown beneath the table.