Biodistribution of 125I-G11 and 125I-L19 at 4 and 24 Hours After Intravenous Injection
| Antibody | Time (h) | Aorta | Blood | Liver | Kidney | Heart | Spleen | Aorta/blood | Blood clearance |
|---|---|---|---|---|---|---|---|---|---|
| G11 | 4 | 5.53 ± 2.22 | 12.32 ± 2.94 | 4.1 ± 0.92 | 6.73 ± 2.09 | 2.13 ± 0.58 | 5.04 ± 1.17 | 0.45 | |
| G11 | 24 | 2.65 ± 0.97 | 1.73 ± 1.16 | 0.99 ± 0.42 | 0.78 ± 0.34 | 0.35 ± 0.20 | 1.18 ± 0.84 | 1.53 | 86% |
| L19 | 4 | 11.41 ± 4.40 | 30.04 ± 3.17 | 4.67 ± 0.77 | 15.11 ± 0.78 | 6.10 ± 0.37 | 9.25 ± 1.14 | 0.38 | |
| L19 | 24 | 15.97 ± 2.29 | 5.10 ± 1.44 | 1.02 ± 0.41 | 3.06 ± 1.69 | 2.13 ± 0.69 | 2.20 ± 0.52 | 3.13 | 83% |
Aorta/blood = %ID/g in aorta divided by %ID/g in blood; blood clearance = 100% (1 – (%ID/g [24 h]/%ID/g [4 h]); n = 4 for each value.
Data are mean (±SD) %ID/g.