Prognostic Variables
| Patient no. | Age* (y) | MRI features† | FET uptake‡ | Initial therapy | Initial cytoreduction§ | Initial histology‖ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Side | Location | Shift | Diffuse | Mean | >1.1 | Max | Mib1¶ | p53# | |||||
| Group A | ||||||||||||||
| 1 | M | 32 | L | O | − | − | 0.7 | − | 1.2 | Resection | Total | A II | 2 | 3 |
| 2 | M | 48 | L | P | − | − | 0.8 | − | 1.2 | Biopsy | − | A II | 1 | 2 |
| 3 | M | 47 | L | F | − | − | 0.8 | − | 1.1 | Biopsy | − | A II | 1 | 1 |
| 4 | M | 48 | L | F (-T) | + | − | 0.9 | − | 1.5 | Biopsy | − | A II | 1 | 2 |
| 5 | F | 41 | R | F | − | − | 0.9 | − | 1.2 | Biopsy | − | A II | 1 | 3 |
| 6 | F | 45 | R | F | + | − | 0.9 | − | 1.7 | Resection | Total | A II | 1 | 3 |
| 7 | F | 40 | L | F | + | − | 0.9 | − | 2.1 | Resection | Subtotal | A II | 1 | 3 |
| 8 | M | 42 | R | F | + | − | 1.0 | − | 1.9 | Resection | Partial | A II | 2 | 3 |
| 9 | M | 44 | L | F (-T) | + | − | 1.0 | − | 1.8 | Biopsy | − | A II | 1 | 2 |
| 10 | M | 35 | L | T (-O) | − | − | 1.1 | − | 1.4 | Biopsy | − | A II | 2 | 2 |
| 11 | F | 45 | R | P | − | − | 1.1 | − | 1.7 | Biopsy | − | A II | 1 | 3 |
| Group B | ||||||||||||||
| 12 | M | 35 | L | F (-T) | + | − | 1.2 | + | 1.8 | Biopsy | − | A II | 1 | 0 |
| 13 | M | 40 | L | T (-O) | − | − | 1.4 | + | 1.5 | Biopsy | − | A II | 1 | 1 |
| 14 | F | 37 | L | F (-T) | − | − | 1.6 | + | 2.4 | Resection | Subtotal | OA II | 1 | 0 |
| 15 | M | 27 | L | T | − | − | 1.6 | + | 2.0 | Biopsy | − | A II | 1 | 3 |
| 16 | M | 47 | L | P | − | − | 1.7 | + | 2.0 | Resection | Subtotal | OA II | 1 | 0 |
| 17 | F | 53 | L | P | − | − | 1.7 | + | 2.3 | Biopsy | − | A II | 1 | 0 |
| 18 | M | 37 | L | F | − | − | 1.8 | + | 2.7 | Resection | Subtotal | A II | 1 | 0 |
| 19 | M | 32 | R | P | − | − | 2.0 | + | 2.7 | Resection | Partial | A II | 1 | 0 |
| 20 | F | 36 | R | F | − | − | 2.0 | + | 2.8 | Resection | Total | O II | 1 | 0 |
| 21 | M | 34 | R | T (-O) | − | − | 2.1 | + | 3.0 | Biopsy | − | O II | 1 | 0 |
| 22 | M | 32 | L | T | − | − | 2.2 | + | 4.7 | Biopsy | − | A II | 2 | 2 |
| 23 | M | 29 | R | T (-O) | + | − | 2.3 | + | 4.1 | Biopsy | − | A II | 2 | 1 |
| 24 | F | 53 | L | F (-T) | + | − | 2.8 | + | 5.1 | Biopsy | − | A II | 1 | 2 |
| Group C | ||||||||||||||
| 25 | M | 61 | R | F (-P) | − | + | 1.3 | + | 1.6 | Biopsy | − | O II | 1 | 0 |
| 26 | M | 39 | R | F | − | + | 1.6 | + | 2.0 | Biopsy | − | A II | 1 | 4 |
| 27 | F | 41 | L | P | + | + | 1.6 | + | 2.3 | Biopsy | − | O II | 1 | 0 |
| 28 | F | 34 | L | T (-O) | + | + | 1.7 | + | 1.7 | Resection | Partial | A II | 1 | 3 |
| 29 | F | 44 | L | F | − | + | 1.9 | + | 2.8 | Biopsy | − | A II | 0 | 0 |
| 30 | F | 33 | L | F | + | + | 1.9 | + | 1.9 | Biopsy | − | A II | 1 | 4 |
| 31 | M | 43 | R | F (-T) | + | + | 1.9 | + | 1.9 | Resection | Subtotal | A II | 1 | 2 |
| 32 | M | 31 | R | P | − | + | 2.3 | + | 4.6 | Resection | Subtotal | A II | 2 | 3 |
| 33 | F | 65 | L | F | + | + | 2.4 | + | 3.9 | Biopsy | − | A II | 1 | 3 |
↵* At initial diagnosis.
↵† L = left hemisphere; R = right hemisphere; O = occipital; P = parietal; F = frontal; T = temporal. In “shift” category, + = space-occupying lesion with ventricular compression or midline shift; in “diffuse” category, + = diffuse lesion (ill-defined borders with inhomogeneous MRI signal), and − = circumscribed lesion (well-defined borders with homogeneous MRI signal).
↵‡ Mean = tumor-to-brain ratio for entire MRI-defined lesion; max = maximum ratio for hot spots within lesion; + = mean ratio above 1.1 threshold; − = mean ratio at or below 1.1 threshold.
↵§ Tumor mass resection > 90% (total), 50%–90% (subtotal), or < 50% (partial).
↵‖ A II = astrocytoma WHO grade II; OA II = oligoastrocytoma WHO grade II; O II = oligodendroglioma WHO grade II.
↵¶ On Ki67 labeling: 0 = no Mib1-positive cells; 1 = less than 1% Mib1-positive cells; 2 = between 1% and <5% Mib1-positive cells.
↵# 0 = no p53-positive cells; 1 = individual p53-positive cells; 2 = moderate fraction of p53-positive cells; 3 = high fraction of p53-positive cells; 4 = not determined.