TABLE 1

Overview of Mouse Conditions and Performed Scans

Test no.	Mouse strain			Cells		PET				CT			BLI			Weight (g)
Test no.	Mouse strain	n	Site	Cell line	Amount	Day	Tracer	Lesions	Mice+	Day	Lesions	Mice+	Day	Lesions	Mice+	Mean	SD
1	nu/nu	3	SC	N2a	1.5E+06	8	¹⁸F-FDG	1	1	8	1	1				27.2	0.5
						13	¹⁸F-FDG	1	1	13	1	1				29.0	0.5
						20	¹⁸F-FDG	3	3	20	3	3				30.8	0.8
2	nu/nu	4	SC	C6	0.5E+06	12	¹⁸F-FDG	4	4	12	4	4				26.5	1.1
						17	¹⁸F-FDG	4	4	17	4	4				28.0	1.6
3	nu/nu	3	IC	A375M	1.5E+06	21	¹⁸F-FDG	1	1	21	0	0				27.8	1.9
						30	¹⁸F-FDG	3	2	30	2	2				25.8	4.2
4	SCID	5	IV	A375M-Fluc	0.7E+06	45	¹⁸F-FDG	6	4	45	6		45	^*	5	31.5	1.1
5	nu/nu	3	IC	B16F0	0.5E+06	17	¹⁸F-FDG	^†	3	17	6	3				19.3	3.5
6	nu/nu	6	IC	A375M-3F	1.5E+06								0	0	0
													3	0	0	26.6	1.4
													6	0	0	27.5	1.6
													9	1	1	28.3	1.3
													15	2	2	29.4	1.6
													18	6	4	28.6	0.7
													22	8	4	29.0	1.3
													26	11	5	29.0	2.2
						28	¹⁸F-FHBG	7	4	28	4	3				27.9	2.7
													29	13	5	27.4	3.4
					^‡	30	¹⁸F-FDG	6	3	30	4	3
						35	¹⁸F-FHBG	10	5	35	5	4				27.4	2.4

↵* Because of limited resolution of BLI, number of lesions could not be determined.
↵† Poor ¹⁸F-FDG uptake in B16F0 metastasis precluded assessment of metastases.
↵‡ Only the 4 mice positive for ¹⁸F-FHBG were scanned.
SC = subcutaneous; IC = intracardiac; IV = intravenous.