PC Xenograft Panel
| Tumor model | Origin | AD/AR/AI | Androgen receptor | PSA |
|---|---|---|---|---|
| PC-295 | LN | AD | + | + |
| PC-310 | PC | AD | + | + |
| PC-82 | PC | AD | + | + |
| PC-346 P* | TURP | AR | + | + |
| PC-346 I | AR | +† | + | |
| PC-346 B | AR | + | + | |
| PC-346 iB | AR | + | + | |
| PC-374 | SSM | AR | + | + |
| PC-133 | Bone | AI | − | − |
| PC-135 | PC | AI | − | − |
| PC-324 | TURP | AI | − | − |
| PC-339 | TURP | AI | − | − |
↵* PC-346 P is derived from a nonprogressive TURP patient, and the 3 sublines were derived from this xenograft.
↵† Androgen receptor mutation (T877A).
AD = androgen-dependent; AR = androgen-independent but androgen-responsive; AI = androgen-independent; PSA = prostate-specific antigen; PC = primary prostate tumor; LN = lymph node metastasis; TURP = transurethral resection of the prostate; SSM = scrotal skin metastasis.