Effects of Cold Ligands on Brain Uptake of Radioactivity 30 Minutes After Injection of 11C-Verapamil into Mice
| Brain uptake of 11C-verapamil | Brain-to-blood ratio | ||||||
|---|---|---|---|---|---|---|---|
| Cold ligand | Dose (mg/kg) | Control (%ID/g) | Treatment (%ID/g) | Ratio | Control | Treatment | Ratio |
| Verapamil | 1 | 0.38 ± 0.05 | 0.36 ± 0.06 | 0.97 | 0.50 ± 0.05 | 0.53 ± 0.06 | 1.07 |
| 5 | 0.38 ± 0.05 | 0.50 ± 0.14 | 1.32 | 0.50 ± 0.05 | 0.65 ± 0.16* | 1.31 | |
| TMSX | 0.5 | 0.33 ± 0.03 | 0.28 ± 0.03* | 0.85 | 0.49 ± 0.06 | 0.46 ± 0.06 | 0.94 |
| MPDX | 1 | 0.36 ± 0.04 | 0.35 ± 0.02 | 0.97 | 0.53 ± 0.04 | 0.53 ± 0.05 | 1.00 |
| MPPF | 1 | 0.36 ± 0.04 | 0.35 ± 0.06 | 0.97 | 0.53 ± 0.04 | 0.54 ± 0.10 | 1.02 |
↵* P < 0.05 (Student t test, compared with control).
Data are mean ± SD (n = 5–6).