TABLE 2

Biodistribution of ^99mTc-(Arg¹¹)CCMSH in Normal and B16/F10 Lung Metastatic Mice

	%ID/g
	2 h		4 h
Tissue	Lung metastases	Normal	Lung metastases	Normal
Lung	2.77 ± 0.98^*	0.52 ± 0.22	2.30 ± 1.78^*	0.65 ± 0.13
Brain	0.02 ± 0.03	0.08 ± 0.07	0.06 ± 0.07	0.10 ± 0.09
Blood	0.39 ± 0.09	0.36 ± 0.07	0.37 ± 0.21	0.19 ± 0.01
Heart	0.46 ± 0.30	0.44 ± 0.27	0.50 ± 0.48	0.26 ± 0.03
Kidney	9.64 ± 0.64	10.20 ± 1.18	6.77 ± 1.08	5.84 ± 0.62
Liver	1.14 ± 0.15	0.94 ± 0.29	0.63 ± 0.23	0.63 ± 0.10
Muscle	0.24 ± 0.18	0.44 ± 0.27	0.46 ± 0.22	0.34 ± 0.31
Spleen	0.45 ± 0.35	0.26 ± 0.23	0.40 ± 0.43	0.85 ± 0.76
Stomach	1.28 ± 0.42	1.65 ± 0.66	0.95 ± 0.24^*	0.23 ± 0.03
Pancreas	0.17 ± 0.16	0.17 ± 0.09	0.33 ± 0.15^*	0.00 ± 0.00
	%ID
Intestine	9.53 ± 1.23	9.77 ± 1.01	11.75 ± 2.60	9.98 ± 2.17
Urine	81.87 ± 1.98	81.58 ± 3.06	82.70 ± 3.18	85.44 ± 1.40
	Uptake ratio of tumor/normal tissue
Lung/blood	7.10	1.44	6.22	3.42
Lung/kidneys	0.29	0.05	0.34	0.11
Lung/liver	2.43	0.55	3.65	1.03
Lung/muscle	11.54	1.18	5.00	1.91

↵* P < 0.05, significance comparison between ^99mTc-(Arg¹¹)CCMSH in pulmonary metastatic melanoma mouse model and ^99mTc-(Arg¹¹)CCMSH in normal mouse model.
Data are presented as %ID/g or as %ID (mean ± SD; n = 4).