Abdominal/Pelvic Lymph Node Imaging Findings for Initial Staging of Patients at Early (4.5 Minutes) and Delayed (20 Minutes) Time Points with Clinical/Pathologic Correlation
| Patient | PSA(ng/mL) | GS | Anti-18F-FACBC imaging visual uptake: early; late SUVmax | Clinical/pathologic correlation | Comments | |
|---|---|---|---|---|---|---|
| 1 | 8.4 | 7 | No uptake | Indeterminate | PLND 11 mo after anti-18F-FACBC scan, 1 node positive | |
| 2 | 71 | 9 | Intense: 11.7 ± 3.2; 4.4 ± 1.3 (n = 5) | Malignant nodes | PSA rising to 290 ng/mL and enlarging pelvic nodes on serial CT scans | |
| 3 | 11 | 7 | No uptake | No malignant nodes | Negative PLND | |
| 4 | 21 | 8 | No uptake | Indeterminate | Not surgical candidate, systemic therapy | |
| 5 | 6.3 | 9 | Moderate fading to mild uptake: 3.7 ± 0.1, 3.2 ± 0.0 (n = 2) | No malignant nodes | Negative PLND; uptake in benign- appearing inguinal nodes | |
| 6 | 16.2 | 6 | No uptake | No malignant nodes | PSA nadir (<0.05) after cryotherapy | |
| 7 | 5.7 | 6 | No uptake | No malignant nodes | No PLND; negative follow-up abdomen/pelvic CT at 6 mo | |
| 8 | 5.7 | 8 | No uptake | No malignant nodes | Negative PLND | |
| 9 | 2.7 | 10 | Intense: 8.3 ± 0.8, 8.4 ± 11.1 (n = 3) | Malignant nodes | Positive biopsy, extensive retroperitoneal nodes | |
| Mean ± SD | Malignant | 10.5 ± 3.0 (early); 5.9 ± 2.4 (late) (n = 8) | 7/9 concordance | |||
| Benign | 3.7 ± 0.1 (early); 3.2 ± 0.0 (late) (n = 2) | |||||
GS = maximum Gleason score; PLND = pelvic lymph node dissection.