Monkey Residence Times of Identified Source Organs
| Residence time (h) | ||
|---|---|---|
| Organ | Baseline | Preblocked |
| Brain | 0.086 ± 0.006 | 0.024 |
| Heart wall | 0.021 ± 0.003 | 0.008 |
| Kidneys | 0.048 ± 0.008 | 0.042 |
| Urinary bladder | 0.012 ± 0.003 | 0.018 |
| Lungs | 0.277 ± 0.01 | 0.067 |
| Liver* | 0.020 | 0.051 |
| Spleen | 0.006 ± 0.004 | — |
| Remainder in body | 0.022 ± 0.12 | 0.282 |
↵* Liver was visible in only 1 study.
Residence times in baseline conditions were averaged over 3 studies using 2 monkeys. One preblocked study was performed by injecting 10.7 mg/kg of nonradioactive PK 11195 three minutes before the radioligand.