TABLE 2

Location and Peaks of Significant Decrease in Relative ¹⁸F-FDG Uptake (Normalized to Global Mean of Whole Brain), Gray-Matter Concentration, and Gray-Matter Volume in AD Patients Compared with Healthy Volunteers

	Coordinate
Structure	x	y	z	t value
¹⁸F-FDG PET
R/L posterior cingulate gyrus	4	−50	22	12.85
R/L precuneus	0	−70	30	8.81
L angular gyrus	−46	−68	42	8.95
R angular gyrus	50	−68	40	7.57
R precentral gyrus	34	6	68	6.12
R hippocampus	−20	−40	−2	5.84
R thalamus	14	−18	14	5.04
R frontal gyrus	54	22	36	5.57
L temporal gyrus	−62	−38	−16	5.50
Optimized VBM
R hippocampus (posterior portion)	26	−36	−2	7.45
L hippocampus (posterior portion)	−20	−36	0	6.26
R pallidum	16	0	−2	6.17
R hippocampus (anterior portion)	18	−4	−16	5.94
R thalamus	14	−10	16	5.69
L parahippocampal gyrus	−16	−2	−18	5.66
Optimized VBM with modulation
R hippocampus	32	−36	−2	6.43
R parahippocampal gyrus	14	−2	−20	5.75
R pallidum	18	0	−2	5.67
R hippocampus	26	−10	−18	5.58
L hippocampus	−28	−40	2	5.51
L parahippocampal gyrus	−14	0	−22	5.18
L thalamus	−12	−20	20	5.10
R caudate	14	−18	22	5.03
R thalamus	14	−28	18	4.94