TABLE 2

Parameter Estimates^* for 4K Model Applied to 16 Mouse Small-Animal PET Studies

	Muscle				Liver				Input Function
Mouse study	K₁ × 10⁻²	k₂ × 10⁻¹	k₃ × 10⁻²	k₄ × 10⁻³	K₁ × 10⁻¹	k₂ × 10⁰	k₃ × 10⁻³	k₄ × 10⁻³	A₁ × 10⁻²	A₂ × 10⁻³	A₃ × 10⁻⁴	λ₁ × 10⁰	λ₂ × 10⁻¹	λ₃ × 10⁻²	λ₄ × 10⁰
m09940	1.60	2.35	20.9	2.95	5.70	1.10	7.58	1.67	12.1	2.74	6.69	11.2	1.53	2.43	41.0
m10296	3.36	4.70	16.6	31.2	5.38	1.08	11.1	2.41	2.72	4.99	28.5	1.47	1.08	1.92	41.0
m10610	2.55	3.72	31.7	4.50	5.42	1.25	7.74	1.63	2.60	5.01	2.90	1.60	1.28	1.64	41.0
m10861	3.30	4.75	17.3	1.90	5.59	1.19	12.4	2.63	5.32	8.80	5.92	4.30	0.70	0.10	41.0
m10911	3.12	4.58	37.7	3.32	5.30	1.66	22.2	3.58	3.63	14.3	5.33	3.70	1.40	0.21	41.0
m11043	3.88	5.42	25.8	2.28	5.35	1.58	25.8	4.07	31.0	12.1	4.46	10.5	1.45	0.71	41.0
m11082	3.92	5.37	17.4	2.82	5.34	1.48	17.0	2.83	8.14	8.53	2.62	9.05	1.21	0.54	41.0
m11122	3.91	5.64	41.5	3.23	5.35	1.43	15.9	2.87	8.74	6.37	4.30	8.98	1.14	1.23	41.0
m11467	2.87	4.22	22.1	12.6	5.57	1.27	21.1	3.83	7.19	5.88	6.66	5.28	1.34	0.47	41.0
m17156	1.88	2.39	0.78	0.15	5.31	1.44	2.83	0.60	8.50	3.29	31.5	13.7	3.01	2.50	41.0
m17332	1.58	2.18	2.40	0.48	6.16	1.00	10.9	2.50	2.94	1.44	19.6	7.21	3.67	2.34	41.0
m17385	3.81	5.34	21.7	34.7	5.36	1.37	21.3	4.10	12.0	4.59	38.8	6.56	1.81	2.23	41.0
m17437	2.83	4.29	9.29	36.3	5.45	1.32	11.7	2.54	6.40	2.61	29.4	9.33	3.84	1.39	41.0
m17464	1.28	1.76	2.44	0.51	5.44	1.27	5.67	1.19	7.10	7.22	35.0	8.92	2.41	1.50	41.0
m17540	2.03	2.87	3.92	0.83	5.31	1.22	5.07	1.07	2.98	5.34	45.4	1.92	1.57	1.38	41.0
m17709	2.21	3.07	4.80	1.13	5.23	1.63	14.5	2.77	1.63	8.31	32.6	1.11	1.02	1.54	41.0

↵* %CVs for each parameter estimate were calculated based on the covariance matrix for each fitted model (not shown); average %CV for all 240 estimated parameters is 20% ± 22%. Units are the same as shown in Table 1.