Lesion- and Examination-Based Sensitivity, Specificity, Accuracy, PPV, and NPV of PET and PET/CT Examinations
| Value of parameter, % (95% exact binomial confidence interval) | |||||||
|---|---|---|---|---|---|---|---|
| Lesion-based analysis | Lesion-based analysis with lesions detected by CT only excluded | Examination-based analysis | |||||
| Status of equivocal foci | Parameter | PET (n = 640*) | PET/CT (n = 733) | PET (n = 609) | PET/CT (n = 609) | PET (n = 163) | PET/CT (n = 163) |
| Excluded | Sensitivity | 71 (64–78) | 87 (81–91) | 87 (80–92) | 86 (79–91) | 92 (81–98) | 96 (87–100) |
| Specificity | 95 (93–97) | 97 (95–99) | 95 (93–97) | 97 (95–99) | 88 (79–94) | 92 (84–97) | |
| Accuracy | 88 (85–91) | 94 (93–97) | 93 (93–97) | 94 (93–97) | 90 (86–98) | 94 (91–100) | |
| PPV | 87 (80–92) | 92 (87–96) | 87 (80–92) | 91 (85–95) | 84 (72–93) | 89 (78–96) | |
| NPV | 88 (85–91) | 95 (93–97) | 95 (93–97) | 95 (93–97) | 94 (86–98) | 97 (91–100) | |
| Classified as benign | Sensitivity | 63 (56–70) | 77 (70–82) | 75 (68–82) | 77 (70–83) | 80 (68–89) | 85 (73–93) |
| Specificity | 96 (94–98) | 98 (96–99) | 96 (94–98) | 97 (95–99) | 91 (84–96) | 94 (88–98) | |
| Accuracy | 86 (82–89) | 92 (90–94) | 90 (89–94) | 92 (89–94) | 87 (81–94) | 91 (84–96) | |
| PPV | 87 (80–92) | 92 (87–96) | 87 (80–92) | 91 (85–95) | 84 (72–93) | 89 (78–96) | |
| NPV | 86 (82–89) | 92 (90–94) | 91 (89–94) | 92 (89–94) | 89 (81–94) | 92 (84–96) | |
| Classified as malignant | Sensitivity | 74 (67–80) | 88 (83–92) | 88 (82–93) | 87 (81–92) | 93 (84–98) | 97 (88–100) |
| Specificity | 84 (80–87) | 85 (82–88) | 84 (80–87) | 91 (88–93) | 65 (55–74) | 70 (60–79) | |
| Accuracy | 81 (85–91) | 86 (93–97) | 85 (93–97) | 90 (93–97) | 75 (86–98) | 80 (91–100) | |
| PPV | 66 (59–72) | 67 (61–73) | 66 (59–72) | 77 (70–83) | 61 (50–71) | 65 (54–75) | |
| NPV | 88 (85–91) | 95 (93–97) | 95 (93–97) | 95 (93–97) | 94 (86–98) | 97 (91–100) | |
↵* Including 31 malignant foci detected by CT but not by PET alone and therefore graded as benign (score, 1).