Biodistribution (%ID/g) of 99mTc-MAG3-SON in Mice Bearing MCF-7 Xenografts
| Biodistribution | 0.5 h | 1 h | 2 h | 4 h | 6 h |
|---|---|---|---|---|---|
| Heart | 0.606 ± 0.173 | 0.488 ± 0.083 | 0.358 ± 0.057 | 0.313 ± 0.097 | 0.454 ± 0.121 |
| Liver | 2.74 ± 0.254 | 2.26 ± 0.221 | 2.287 ± 0.298 | 1.93 ± 0.177 | 1.954 ± 0.123 |
| Spleen | 0.939 ± 0.033 | 0.595 ± 0.065 | 0.52 ± 0.032 | 0.448 ± 0.076 | 0.415 ± 0.054 |
| Lung | 2.01 ± 0.144 | 1.68 ± 0.132 | 0.883 ± 0.146 | 0.854 ± 0.189 | 0.841 ± 0.032 |
| Kidney | 9.218 ± 0.78 | 6.74 ± 1.08 | 4.94 ± 0.549 | 4.38 ± 1.07 | 3.23 ± 0.477 |
| Stomach | 2.42 ± 0.191 | 1.55 ± 0.155 | 1.62 ± 0.147 | 1.61 ± 0.185 | 1.17 ± 0.184 |
| Small intestine | 1.505 ± 0.162 | 1.982 ± 0.183 | 1.1 ± 0.08 | 0.427 ± 0.085 | 0.259 ± 0.049 |
| Bladder | 1.909 ± 0.162 | 1.474 ± 0.124 | 0.987 ± 0.123 | 0.365 ± 0.097 | 0.309 ± 0.168 |
| Skeletal muscle | 0.523 ± 0.036 | 0.297 ± 0.025 | 0.232 ± 0.035 | 0.239 ± 0.053 | 0.211 ± 0.021 |
| Bone marrow | 1.22 ± 0.155 | 0.707 ± 0.099 | 0.497 ± 0.121 | 0.554 ± 0.163 | 0.328 ± 0.11 |
| Blood | 1.78 ± 0.173 | 1.67 ± 0.134 | 0.947 ± 0.163 | 0.779 ± 0.12 | 0.476 ± 0.056 |
| Tumor | 0.772 ± 0.082 | 0.663 ± 0.127 | 0.59 ± 0.095 | 0.503 ± 0.051 | 0.417 ± 0.09 |
Each value represents average of 5 mice ± SD and is expressed as %ID radioactivity per gram organ or tissue.