TABLE 1

Biodistribution of ¹⁸⁶Re-MAG3-HBP and ¹⁸⁶Re-HEDP in Rats

	Time after administration
Tissue	10 min	3 h	24 h
	¹⁸⁶Re-MAG3-HBP (%ID/g tissue)
Blood	0.831 ± 0.134^*	0.015 ± 0.008^†	0.003 ± 0.000^†
Liver	0.213 ± 0.031^*	0.063 ± 0.025	0.051 ± 0.009^†
Kidney	1.551 ± 0.115	0.539 ± 0.187^*	0.473 ± 0.074
Intestine	0.153 ± 0.015^*	0.235 ± 0.173	0.151 ± 0.081
Spleen	0.180 ± 0.018^*	0.030 ± 0.009	0.027 ± 0.005^*
Pancreas	0.196 ± 0.024	0.013 ± 0.003^*	0.008 ± 0.002
Lung	0.566 ± 0.059^†	0.040 ± 0.009^*	0.037 ± 0.031
Stomach^‡	0.525 ± 0.198	0.302 ± 0.134^*	0.152 ± 0.176^*
Femur	2.129 ± 0.142^*	3.943 ± 0.270^†	4.097 ± 0.181^†
Muscle	0.129 ± 0.028	0.014 ± 0.009	0.004 ± 0.001
	¹⁸⁶Re-HEDP (%ID/g tissue)
Blood	0.572 ± 0.103	0.074 ± 0.025	0.025 ± 0.006
Liver	0.162 ± 0.020	0.035 ± 0.005	0.025 ± 0.005
Kidney	1.807 ± 0.613	0.859 ± 0.162	0.386 ± 0.115
Intestine	0.126 ± 0.012	0.074 ± 0.039	0.082 ± 0.039
Spleen	0.133 ± 0.019	0.032 ± 0.005	0.020 ± 0.003
Pancreas	0.164 ± 0.021	0.019 ± 0.003	0.013 ± 0.004
Lung	0.414 ± 0.049	0.067 ± 0.014	0.032 ± 0.013
Stomach^‡	0.710 ± 0.323	0.729 ± 0.284	0.764 ± 0.440
Femur	1.586 ± 0.365	1.913 ± 0.272	1.798 ± 0.621
Muscle	0.117 ± 0.024	0.011 ± 0.005	0.005 ± 0.003

↵* P < 0.05 vs. ¹⁸⁶Re-HEDP.
↵† P < 0.01 vs. ¹⁸⁶Re-HEDP.
↵‡ Data are expressed as percentage injected dose (%ID).
Data are expressed as mean ± SD for 4 animals.