Comparison of Data for Striatum and Cerebellum
| Parameter | 11C-d-methamphetamine | 11C-l-methamphetamine |
|---|---|---|
| % dose/cm3 (peak) | ||
| Striatum | 0.033 ± 0.008 | 0.036 ± 0.003 |
| Cerebellum | 0.034 ± 0.01 | 0.034 ± 0.004 |
| Peak time (min) | ||
| Striatum | 7.2 ± 2.3 | 7.5 ± 2.6 |
| Cerebellum | 4.5 ± 4.5 | 4.5 ± 1.5 |
| Clearance half-time from peak (min) | ||
| Striatum | 80.3 ± 18.6 | 98.5 ± 22.3 |
| Cerebellum | 59.3 ± 18.3 | 67.5 ± 12.3 |
| DVR (Striatum:cerebellum) | 1.22 ± 0.04 | 1.22 ± 0.027 |
| Plasma integral for total 11C at 60 min* | 2,411 ± 399 (1,348 ± 33) | 1,833 ± 203 (1,351 ± 51) |
↵* There was a trend toward greater 11C in plasma at 60 min for d-enantiomer (P < 0.08). Data in parentheses are fraction of 11C as methamphetamine (mean ± SD, n = 3).