Equilibrium Distribution Volumes (Ved) for Cerebellum in Patients With and Without Oral Pretreatment With 200 mg of Carbidopa*
| With carbidopa pretreatment | Without carbidopa pretreatment | ||||
|---|---|---|---|---|---|
| Patient | Model | Study | Ved | Study | Ved |
| A | 2C-3p | 1 | 1.49 | 2 | 1.98 |
| 2C-3p+ | 2 | 1.21 | |||
| Logan | 1 | 1.14 | 2 | 1.88 | |
| Logan+ | 2 | 1.16 | |||
| B | 2C-3p | 1 | 1.08 | 2 | 1.77 |
| 2C-3p+ | 2 | 1.03 | |||
| Logan | 1 | 1.11 | 2 | 1.82 | |
| Logan+ | 2 | 1.21 | |||
↵* Values were obtained with 2-compartment model (2C) with 3 parameters (3p) or Logan graphical analysis. + indicates that MET correction was applied to input function (Eq. 2). Effect of peripheral MET correction is shown in last column. Bold type indicates directly comparable conditions.