TABLE 2

Kinetic Modeling of Tumors^*

Parameter	2C-3p	3C-5p	3C-5p	3C-4p with k₄ = 0	Patlak-2p	Logan-2p
Metabolite correction	No	No	Yes	Yes	No	No
k₁	0.347 ± 0.399	0.271 ± 0.259	0.225 ± 0.179	0.206 ± 0.178
k₂	0.219 ± 0.188	0.205 ± 0.134	0.169 ± 0.077	0.129 ± 0.073		0.143 ± 0.495
k₃		0.003 ± 0.004	0.031 ± 0.019	0.014 ± 0.005
k₄		0.011 ± 0.025	0.016 ± 0.011
K		0.003 ± 0.004	0.028 ± 0.016	0.017 ± 0.007	0.001 ± 0.006
V_b	0.03 ± 0.02	0.15 ± 0.10	0.18 ± 0.11	0.18 ± 0.11
V_ed	1.44 ± 0.56	1.23 ± 0.52	1.27 ± 0.58	1.52 ± 0.65	2.10 ± 0.89	1.53 ± 0.57
WRSS	2,370 ± 3,372	1,632 ± 3,512	470 ± 685	903 ± 1,657
n (P < 0.05)	Reference	22	48	33

↵* Estimates of fitted parameters k₁–k₄, influx rate constant K, blood volume fraction in tissue (V_b), and equilibrium distribution volume (V_ed) were determined. Results are expressed as mean ± SD for 61 malignant tumors in 35 patients. Same model structures and corrections as those described in Table 1 were tested. See Table 1 for definitions of abbreviations as well.