TABLE 1

Averages of NET B_max, ³H-Mazindol Binding Affinity (K_D), and HED Tissue Concentrations

6-OHDA dose (mg/kg)	n	NET B_max (fmol/mg protein)	K_D (nmol/L)	HED concentration at 30 min (%ID/g)
6-OHDA dose (mg/kg)	n	NET B_max (fmol/mg protein)	K_D (nmol/L)	Whole heart	Left atrium	Right atrium	Left ventricle	Right ventricle	Blood
0	5	388 ± 23	0.72 ± 0.07	2.89 ± 0.35	2.95 ± 0.36	2.60 ± 0.27	2.73 ± 0.34	3.51 ± 0.46	0.073 ± 0.006
7	5	266 ± 45	0.73 ± 0.14	2.14 ± 0.33	2.01 ± 0.52	2.25 ± 0.64	1.96 ± 0.34	2.73 ± 0.34	0.081 ± 0.011
11	5	167 ± 94	1.08 ± 0.32	1.18 ± 0.87	0.74 ± 0.46	1.35 ± 0.84	1.09 ± 0.80	1.54 ± 1.26	0.105 ± 0.013
15	5	181 ± 65	0.94 ± 0.24	1.33 ± 0.56	0.93 ± 0.76	1.34 ± 0.48	1.26 ± 0.56	1.65 ± 0.59	0.105 ± 0.011
22	5	100 ± 31	0.95 ± 0.48	0.76 ± 0.32	0.32 ± 0.09	0.56 ± 0.29	0.75 ± 0.32	0.90 ± 0.38	0.102 ± 0.009
100	5	31 ± 6	1.83 ± 0.91	0.22 ± 0.06	0.18 ± 0.05	0.22 ± 0.05	0.22 ± 0.06	0.22 ± 0.05	0.091 ± 0.023