Comparison of Visual and Quantitative Results and Histopathologic Findings at Various Times of Sacrifice
| Ratio* | ||||
|---|---|---|---|---|
| Time of sacrifice | Visual score | Early | Delayed | Histopathologic findings |
| RFA-treated normal-lung groups | ||||
| 1 d | 1.3 ± 0.6 | 2.9 ± 1.0 | 3.3 ± 0.8 | Inflammation, congestion, and hemorrhage |
| 1 wk | 2.2 ± 0.3 | 4.1 ± 0.6 | 5.2 ± 0.9 | Marked infiltration of neutrophils |
| 2 wk | 2.0 ± 0.0 | 4.1 ± 1.0 | 5.3 ± 1.5 | Inflammatory changes (same as at 1 wk) |
| 4 wk | 1.3 ± 0.5 | 3.1 ± 0.5 | 3.6 ± 1.1 | Fibrosis of granulomatous changes |
| 8 wk | 1.0 ± 0.0 | 1.8 ± 0.1 | 2.3 ± 0.1 | Small granulation; size reduction of necrotic lesions |
| VX2 groups | ||||
| Without RFA | 2.9 ± 0.4 | 6.6 ± 2.1 | 8.6 ± 3.3 | Viable VX2 cells |
| With RFA (ablated tumor), 1 d | 0.3 ± 0.5 | 0.8 ± 0.4 | 1.1 ± 0.7 | Ongoing necrosis of tumor cells |
| With RFA (outer zone), 1 d | 1.3 ± 0.5 | 3.5 ± 0.9 | 4.4 ± 1.2 | Inflammation, congestion, and hemorrhage |
| With RFA (ablated tumor), 1 wk | 0.4 ± 0.5 | 1.2 ± 0.5 | 1.5 ± 0.7 | Ongoing necrosis of tumor cells |
| With RFA (outer zone), 1 wk | 1.7 ± 0.5 | 3.9 ± 0.7 | 4.7 ± 1.1 | Strong infiltration of neutrophils |
↵* Data are RF/M for RFA-treated normal-lung groups and T/M for VX2 groups.