Demographic and Clinical Features of Sample
| Parameter | All patients (n = 65) | Responders (n = 35) | Nonresponders (n = 30) | P value |
|---|---|---|---|---|
| Age (y) | 45.3 ± 1.7 | 46.0 ± 2.3 | 44.5 ± 2.5 | 0.66 |
| Age of onset (y) | 35.1 ± 1.5 | 35.7 ± 1.9 | 34.4 ± 2.5 | 0.68 |
| Duration of disease (y) | 9.7 ± 1.4 | 9.6 ± 2.0 | 9.8 ± 1.9 | 0.95 |
| No. of episodes | 2.7 ± 0.3 | 2.5 ± 0.3 | 3.2 ± 0.6 | 0.27 |
| Sex (male/female) | 18/47 | 10/25 | 8/22 | 0.54 |
| Comorbidity (yes/no) | 37/28 | 20/15 | 17/13 | 0.58 |
| Unipolar/bipolar | 60/5 | 33/2 | 27/3 | 0.43 |
| Antidepressant drug (mg/d) | 23.6 ± 7 | 23.1 ± 9 | 24.3 ± 1.1 | 0.41 |
| Benzodiazepines (yes/no) | 42/23 | 21/14 | 21/9 | 0.28 |
| Benzodiazepines (mg/d) | 1.87 ± 0.15 | 1.7 ± 0.2 | 2.0 ± 0.2 | 0.29 |
| HRSD (t1) | 26.5 ± 0.7 | 26.6 ± 0.9 | 26.4 ± 1.1 | 0.89 |
| HRSD (t2) | 14.8 ± 0.9 | 9.9 ± 0.6 | 20.5 ± 1.2 | 0.00* |
↵*P < 0.01.
Continuous variables are expressed as mean ± SE and categoric data are expressed as number of patients. Continuous variables were compared by Student unpaired t test. Categoric variables were compared by Pearson χ2 analysis. Both groups did not differ significantly in demographic or clinical features.