BBN Receptor Subtype Specificity of 175Lu-AMBA by Receptor Autoradiography in Human Tissues, as Measured by Displacement Assay with Universal 125I-BBN Ligand on Human Tissue Samples
| IC50 (nmol/L) | |||
|---|---|---|---|
| Compound | NMB-R | GRP-R | bb3-R |
| 175Lu-AMBA | 0.9 ± 0.1 (n = 4) | 0.8 ± 0.1 (n = 5) | >1,000 (n = 3) |
| Universal ligand | 0.8 ± 0.1 (n = 3) | 0.7 ± 0.1 (n = 3) | 1.1 ± 0.1 (n = 3) |
Binding affinities of 175Lu-AMBA and universal ligand [d-Tyr6,β-Ala11,Phe13,Nle14]BBN[6–14] for 3 BBN-R subtypes as expressed in human tumor tissues: human ileal carcinoid (NMB-R), human prostate carcinoma (GRP-R), and human bronchial carcinoid (bb3-R). Data are expressed as mean ± SEM.