TABLE 3

Results of Biochemistry and Hematology Analyses at 15 Days After Injection of 111In-DTPA-hEGF or Unlabeled DTPA-hEGF into BALB/c Mice

Mean value after injection of*:
Parameter111In-DTPA-hEGFDTPA- hEGFNormal range†
WBC (109/L)6.47.45.0–13.7
RBC (1012/L)8.19.27.9–10.1
Hb (g/L)137153110–145
Hct0.3980.4510.400
Platelets (109/L)521ND600–1,200
ALT (U/L)233628–184
Cr (μmol/L)3351119–155

  • ↵* Mean value for blood or serum samples pooled from 7 mice administered 44.4 MBq (3–30 μg) of 111In-DTPA-hEGF or equivalent amount of unlabeled DTPA-hEGF. ND = not determined because of subquality of sample obtained.

  • ↵† Expected normal range was obtained from Olfert et al. (10).