Clearance, Protein Binding, Erythrocyte Binding, and Urine Excretion of 99mTc(CO)3(LAN) Complexes Compared with 131I-OIH in Humans (n = 3)
| Isomer | 99mTc(CO)3(LAN) clearance (mL/min) | 131I-OIH clearance (mL/min) | 99mTc(CO)3(LAN)/ 131I-OIH clearance ratio (%) | Protein binding (%) | Erythrocyte binding (%) | 99mTc(CO)3(LAN)/131I-OIH 30-min urine excretion ratio (%) | 99mTc(CO)3(LAN)/ 131I-OIH 180-min urine excretion ratio (%) |
|---|---|---|---|---|---|---|---|
| meso-LAN | 228 ± 33 | 548 ± 37 | 42 ± 5 | 10 ± 0.6 | 24 ± 3.6 | 57 ± 6 | 85 ± 6 |
| dd,ll-LAN | 176 ± 8 | 528 ± 13 | 33 ± 2 | 2 ± 0.0 | 21 ± 8.6 | 45 ± 3 | 77 ± 6 |
Data are mean ± SD.