Percentage Injected Dose in Rats of 99mTc(CO)3(meso-LAN) and 99mTc(CO)3(dd,ll-LAN) Compared with 131I-OIH in Blood, Urine, and Selected Organs at 10 and 60 Minutes (n = 5)
| Blood | Kidneys | Urine | Liver | Bowel | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Isomer | 99mTc | 131I-OIH | 99mTc | 131I-OIH | 99mTc | 131I-OIH | 99mTc/131I-OIH ratio | 99mTc | 131I-OIH | 99mTc | 131I-OIH |
| meso-LAN | |||||||||||
| 10 min | 4.1 ± 0.4 | 3.3 ± 0.5 | 6.5 ± 2.8 | 4.9 ± 3.5 | 41.0 ± 7.3 | 59.9 ± 11.5 | 69 ± 6 | 4.2 ± 0.6 | 2.0 ± 0.2 | 1.2 ± 0.3 | 1.0 ± 0.2 |
| 60 min | 0.6 ± 0.1 | 0.5 ± 0.1 | 1.2 ± 0.3 | 0.7 ± 0.3 | 77.9 ± 3.2 | 87.5 ± 8.2 | 89 ± 6 | 1.2 ± 0.5 | 0.8 ± 0.5 | 1.7 ± 0.1 | 0.9 ± 0.2 |
| dd,ll-LAN | |||||||||||
| 10 min | 5.7 ± 0.7 | 4.0 ± 0.6 | 9.5 ± 0.9 | 4.6 ± 1.0 | 33.4 ± 3.9 | 59.2 ± 3.6 | 56 ± 4 | 3.9 ± 0.5 | 2.3 ± 0.2 | 1.7 ± 0.4 | 1.1 ± 0.2 |
| 60 min | 0.7 ± 0.2 | 0.4 ± 0.1 | 1.2 ± 0.3 | 0.3 ± 0.1 | 76.4 ± 7.2 | 88.0 ± 7.8 | 87 ± 4 | 0.8 ± 0.3 | 0.5 ± 0.3 | 4.6 ± 0.7 | 0.9 ± 0.1 |
Data are mean ± SD.