TABLE 1

Procedure Schedule for Rats

	1					2					3					4					5					6
Group Day	−1	0	1	7	14	−1	0	1	7	14	−1	0	1	7	14	−1	0	1	7	14	−1	0	1	7	14	−1	0	1	7	14
FHBG (μg/kg)		0					14					0					14					0					14
Blood chemistry and hematology	X		X					X						X					X						X					X
Urinalysis	X		X					X						X					X						X					X
Respiratory rate																					X	X	X	X	X	X	X	X	X	X
Pulse oximetry																					X	X	X	X	X	X	X	X	X	X
ECG																					X	X	X	X	X	X	X	X	X	X
Blood pressure (tail cuff)																					X	X	X	X	X	X	X	X	X	X
Blood pressure (direct femoral artery)																									X					X
Weight measurement	X		X			X		X			X		X	X		X		X	X		X		X	X	X	X		X	X	X
Necropsy			X					X						X					X						X					X
Histopathology																									X					X

ECG=electrocardiogram.