Uptake of 18F-FDG and d-isomers of 11C-MET, 11C-CMT, and 18F-FMT in Turpentine-Induced Inflammatory Tissue of Tumor-Bearing mice
| Organ | 18F-FDG | d-11C-MET | d-11C-CMT | d-18F-FMT |
|---|---|---|---|---|
| Blood | 0.239 ± 0.049 | 0.523 ± 0.064 | 0.405 ± 0.032 | 0.391 ± 0.045 |
| Tumor | 0.997 ± 0.064 | 3.087 ± 0.487 | 2.078 ± 0.178 | 2.570 ± 0.547 |
| T/B | 4.291 ± 0.064 | 5.902 ± 0.304 | 5.131 ± 0.344 | 6.573 ± 0.486 |
| Muscle | 0.437 ± 0.062 | 0.607 ± 0.037 | 0.462 ± 0.033 | 0.482 ± 0.040 |
| M/B | 1.759 ± 0.224 | 1.125 ± 0.023 | 1.396 ± 0.045 | 1.294 ± 0.096 |
| Inflammation | 1.157 ± 0.123 | 0.657 ± 0.057 | 0.429 ± 0.005 | 0.470 ± 0.085 |
| I/B | 4.895 ± 0.485 | 1.202 ± 0.046 | 1.117 ± 0.022 | 1.356 ± 0.125 |
T/B = tumor-to-blood ratio; M/B = muscle-to-blood ratio; I/B = inflammatory tissue-to-blood ratio.
Mice (n = 5 at each time point) were injected intravenously with 5 MBq of labeled ligand via tail vein and killed at 60 min after injection; tissue samples were rapidly removed, and weight and radioactivity were measured. Data in blood, tumor, muscle, and inflammatory tissue are expressed as SUV.