Uptake of l- and d-11C-MET in Tumor-Bearing Mice
| Organ | Isomer | 5 min | 15 min | 30 min | 60 min |
|---|---|---|---|---|---|
| Blood | l | 0.593 ± 0.027 | 0.300 ± 0.017 | 0.256 ± 0.016 | 0.260 ± 0.017 |
| d | 1.365 ± 0.029 | 0.855 ± 0.053 | 0.610 ± 0.010 | 0.523 ± 0.064 | |
| Heart | l | 1.329 ± 0.062 | 0.940 ± 0.155 | 0.756 ± 0.005 | 0.710 ± 0.020 |
| d | 1.315 ± 0.103 | 1.208 ± 0.040 | 1.033 ± 0.031 | 0.798 ± 0.033 | |
| Lung | l | 1.196 ± 0.068 | 0.994 ± 0.141 | 0.998 ± 0.025 | 0.900 ± 0.035 |
| d | 1.409 ± 0.070 | 1.100 ± 0.007 | 1.020 ± 0.023 | 0.950 ± 0.014 | |
| Liver | l | 3.117 ± 0.186 | 4.350 ± 0.788 | 4.222 ± 0.311 | 4.755 ± 0.792 |
| d | 1.469 ± 0.138 | 1.844 ± 0.129 | 2.282 ± 0.081 | 3.184 ± 0.066 | |
| Kidney | l | 1.973 ± 0.023 | 2.120 ± 0.192 | 1.992 ± 0.180 | 1.961 ± 0.051 |
| d | 2.458 ± 0.046 | 2.872 ± 0.408 | 2.906 ± 0.270 | 3.573 ± 0.110 | |
| Spleen | l | 1.666 ± 0.125 | 1.489 ± 0.164 | 1.904 ± 0.212 | 1.631 ± 0.166 |
| d | 1.740 ± 0.132 | 1.522 ± 0.115 | 1.575 ± 0.061 | 1.660 ± 0.184 | |
| Muscle | l | 0.744 ± 0.020 | 0.621 ± 0.047 | 0.524 ± 0.022 | 0.381 ± 0.021 |
| d | 0.619 ± 0.013 | 0.696 ± 0.045 | 0.699 ± 0.027 | 0.607 ± 0.037 | |
| Bone | l | 0.914 ± 0.031 | 0.980 ± 0.130 | 0.924 ± 0.068 | 0.919 ± 0.045 |
| d | 0.893 ± 0.104 | 0.836 ± 0.034 | 0.867 ± 0.038 | 0.822 ± 0.047 | |
| Intestine | l | 1.978 ± 0.295 | 1.988 ± 0.623 | 2.945 ± 0.373 | 2.807 ± 0.067 |
| d | 1.230 ± 0.125 | 1.187 ± 0.052 | 1.417 ± 0.126 | 1.765 ± 0.085 | |
| Gut | l | 1.013 ± 0.084 | 1.077 ± 0.151 | 1.291 ± 0.045 | 1.281 ± 0.086 |
| d | 0.802 ± 0.107 | 0.767 ± 0.082 | 0.829 ± 0.074 | 0.872 ± 0.033 | |
| Pancreas | l | 5.635 ± 1.171 | 7.098 ± 1.058 | 7.819 ± 0.905 | 7.626 ± 0.982 |
| d | 8.279 ± 2.260 | 7.931 ± 1.870 | 6.441 ± 0.042 | 7.358 ± 0.493 | |
| Brain | l | ND | ND | ND | 0.495 ± 0.028 |
| d | ND | ND | ND | 0.795 ± 0.114 | |
| Tumor | l | 1.560 ± 0.326 | 1.348 ± 0.204 | 1.292 ± 0.254 | 1.182 ± 0.324 |
| d | 1.952 ± 0.253 | 2.829 ± 0.074 | 2.887 ± 0.241 | 3.087 ± 0.487 |
ND = not determined.
Mice (n = 5 at each time point) were injected intravenously with 5 MBq of l- or d-11C-MET via tail vein and killed at 5, 15, 30, and 60 min after injection; tissue samples were rapidly removed, and weight and radioactivity were measured. Data are expressed as SUV.