Biodistributions of 125I-His6-(ZHER2:4)2 and 99mTc-His6-(ZHER2:4)2 in Tumor-Bearing Mice
| %IA/g of organ or tissue* | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 h | 4 h | 8 h | 12 h | |||||
| Organ or tissue | 125I | 99mTc | 125I | 99mTc | 125I | 99mTc | 125I | 99mTc |
| Blood | 3.83 ± 0.29 | 1.16 ± 0.16 | 0.56 ± 0.14 (0.63 ± 0.09) | 0.54 ± 0.04 (0.47 ± 0.14) | 0.09 ± 0.03 | 0.54 ± 0.23 | 0.04 ± 0.01 | 0.40 ± 0.03 |
| Heart | 1.34 ± 0.12 | 0.70 ± 0.07 | 0.31 ± 0.14 (0.22 ± 0.02) | 0.43 ± 0.04 (1.19 ± 0.20) | 0.03 ± 0.02 | 0.58 ± 0.14 | 0.03 ± 0.01 | NM |
| Lungs | 2.56 ± 0.10 | 1.18 ± 0.10 | 0.44 ± 0.12 (0.48 ± 0.06) | 0.90 ± 0.04 (1.35 ± 0.04) | 0.12 ± 0.04 | 1.22 ± 0.12 | 0.06 ± 0.02 | NM |
| Liver | 5.10 ± 0.25 | 6.07 ± 0.42 | 1.00 ± 0.38 (1.06 ± 0.37) | 6.97 ± 0.28 (7.38 ± 0.92) | 0.09 ± 0.02 | 7.32 ± 3.21 | 0.04 ± 0.01 | 6.77 ± 0.53 |
| Spleen | 1.41 ± 0.10 | 1.27 ± 0.05 | 0.19 ± 0.04 (0.20 ± 0.03) | 0.97 ± 0.05 (1.92 ± 0.30) | 0.04 ± 0.01 | 1.59 ± 0.06 | 0.02 ± 0.01 | NM |
| Pancreas | 2.43 ± 0.08 | 0.79 ± 0.09 | 0.26 ± 0.05 (0.44 ± 0.14) | 0.62 ± 0.05 (1.01 ± 0.14) | 0.04 ± 0.01 | 1.10 ± 0.49 | 0.01 ± 0.01 | NM |
| Kidneys | 69 ± 10 | 92.53 ± 0.73 | 30 ± 3 (25 ± 4) | 89 ± 10 (104 ± 17) | 8.22 ± 2.19 | 79 ± 37 | 3.61 ± 0.86 | 75 ± 10 |
| Stomach | 2.26 ± 0.29 | 1.55 ± 0.19 | 0.76 ± 0.21 (0.81 ± 0.16) | 1.76 ± 0.12 (1.96 ± 0.20) | 0.33 ± 0.17 | 1.19 ± 0.38 | 0.05 ± 0.02 | 0.93 ± 0.12 |
| Salivary glands | 2.70 ± 0.53 | 1.63 ± 0.03 | 1.39 ± 0.31 (1.14 ± 0.13) | 2.55 ± 0.29 (2.28 ± 0.21) | 0.22 ± 0.06 | 1.20 ± 0.35 | 0.04 ± 0.02 | 1.20 ± 0.10 |
| Tumor | 3.23 ± 0.12 | 1.94 ± 0.58 | 2.27 ± 0.55 (0.53 ± 0.06) | 2.61 ± 0.41 (1.47 ± 0.16) | 1.06 ± 0.20 | 2.64 ± 0.86 | 0.68 ± 0.09 | 2.62 ± 0.48 |
| Skin | 3.31 ± 1.18 | 1.42 ± 0.19 | 0.27 ± 0.09 (0.80 ± 0.50) | 1.69 ± 0.77 (1.94 ± 0.78) | 0.12 ± 0.06 | 1.57 ± 0.25 | 0.03 ± 0.00 | NM |
| Muscle | 0.84 ± 0.12 | 0.34 ± 0.06 | 0.07 ± 0.03 (0.10 ± 0.02) | 0.32 ± 0.08 (0.50 ± 0.03) | 0.01 ± 0.00 | 0.30 ± 0.07 | NM | NM |
| Bone | 0.56 ± 0.11 | 0.58 ± 0.16 | 0.08 ± 0.04 (0.20 ± 0.09) | 0.55 ± 0.18 (2.54 ± 0.99) | 0.04 ± 0.01 | 0.81 ± 0.34 | 0.04 ± 0.01 | NM |
| Thyroid | 0.08 ± 0.03 | 0.05 ± 0.01 | 0.15 ± 0.07 (0.16 ± 0.02) | 0.06 ± 0.01 (0.11 ± 0.01) | 0.24 ± 0.08 | 0.03 ± 0.01 | 0.20 ± 0.04 | 0.03 ± 0.02 |
↵* Each value represents mean for 4 animals ± SD. Values for thyroid are presented as percent injected radioactivity per organ. Values in parentheses are for 4 animals that were preinjected with large molar excess of nonlabeled dimer. NM = nonmeasurable.