TABLE 3

18F-FET PET Results of Standard Method Applied to Single Time Frames of Dynamic Evaluation (Mean ± SD) and Statistical Differences Between Histopathologic Groups

SUV90SUV90-to-background ratio
ParameterFrame 12 (5–10 min)Frame 13 (10–15 min)Frame 14 (15–20 min)Frame 15 (20–30 min)Frame 16 (30–40 min)Frame 12 (5–10 min)Frame 13 (10–15 min)Frame 14 (15–20 min)Frame 15 (20–30 min)Frame 16 (30–40 min)
No recurrence (n = 4)1.69 ± 0.421.83 ± 0.491.97 ± 0.492.13 ± 0.562.25 ± 0.581.66 ± 0.261.80 ± 0.351.94 ± 0.272.09 ± 0.382.22 ± 0.44
Histologic type
 Astrocytoma, WHO II (n = 13)2.12 ± 0.672.38 ± 0.742.58 ± 0.862.70 ± 0.712.84 ± 0.761.88 ± 0.582.10 ± 0.642.27 ± 0.732.39 ± 0.572.51 ± 0.61
 Anaplastic astrocytoma, WHO III (n = 9 + 1)*2.69 ± 0.753.01 ± 0.892.99 ± 1.052.97 ± 0.972.85 ± 0.912.42 ± 0.382.69 ± 0.372.66 ± 0.482.64 ± 0.412.53 ± 0.38
 Glioblastoma multiforme, WHO IV (n = 15 + 1)*2.75 ± 0.623.04 ± 0.733.03 ± 0.742.97 ± 0.782.89 ± 0.812.63 ± 0.622.87 ± 0.602.85 ± 0.532.79 ± 0.522.69 ± 0.48
 All astrocytoma, WHO III/IV (n = 24 + 2)*2.73 ± 0.663.03 ± 0.783.02 ± 0.852.97 ± 0.842.87 ± 0.832.55 ± 0.542.80 ± 0.532.78 ± 0.512.73 ± 0.472.63 ± 0.44
 Oligoastrocytoma, WHO II (n = 3)2.78 ± 1.033.23 ± 1.073.45 ± 1.123.53 ± 1.263.63 ± 1.232.39 ± 0.762.78 ± 0.782.97 ± 0.853.02 ± 0.903.11 ± 0.85
 Oligoastrocytoma, WHO III (n = 1)3.803.353.092.892.654.203.703.423.192.93
 All WHO II (n = 16)2.25 ± 0.762.54 ± 0.842.74 ± 0.942.86 ± 0.852.99 ± 0.871.97 ± 0.622.23 ± 0.692.40 ± 0.782.51 ± 0.662.62 ± 0.67
 All WHO III/IV (n = 25 + 2)2.77 ± 0.673.04 ± 0.773.02 ± 0.842.97 ± 0.822.86 ± 0.822.61 ± 0.622.83 ± 0.542.80 ± 0.512.75 ± 0.472.64 ± 0.44
P
 No recurrence vs. recurrence0.0070.0080.0100.0270.0500.0010.0040.0020.0240.075
 No recurrence vs. low-grade astrocytomas0.0450.0360.0310.0410.0430.0890.0720.0500.0760.101
 No recurrence vs. low-grade tumors0.0400.0290.0250.0380.0400.0750.0550.0330.0670.093
 Low- vs. high-grade astrocytomas0.0070.0090.0730.1510.4590.0010.0010.0190.0380.261
 All low- vs. high-grade tumors0.0160.0310.1670.3390.3190.0010.0030.0410.1060.454
  • * Added numbers reflect second biopsy in same patient.