TABLE 1

Comparisons Between Rats with LAD Occlusion and Those with Sham Operation: Pinhole SPECT Data at 48 Hours and at 12 Weeks After Surgery and Absolute Variations of These Data between 48 Hours and 12 Weeks

ParameterLAD occlusion (n = 20)Sham operation (n = 9)P value
48-h pinhole SPECT
 Necrotic myocardium (% LV)14 ± 140 ± 00.004
 End-diastolic volume (μL)320 ± 84293 ± 48NS
 End-systolic volume (μL)146 ± 71113 ± 10NS
 Ejection fraction (%)56 ± 1261 ± 4NS
12-wk pinhole SPECT
 Necrotic myocardium (% LV)16 ± 160 ± 00.004
 End-diastolic volume (μL)501 ± 191343 ± 460.01
 End-systolic volume (μL)294 ± 183154 ± 240.03
 Ejection fraction (%)46 ± 1355 ± 50.05
Absolute variations between 48 h and 12 wk
 Necrotic myocardium (% LV)2 ± 30 ± 0NS
 End-diastolic volume (μL)182 ± 14950 ± 150.002
 End-systolic volume (μL)148 ± 13340 ± 170.01
 Ejection fraction (%)−10 ± 9−5 ± 6NS
  • LAD = left anterior descending coronary artery; LV = left ventricle; NS = nonsignificant.