Comparisons Between Rats with LAD Occlusion and Those with Sham Operation: Pinhole SPECT Data at 48 Hours and at 12 Weeks After Surgery and Absolute Variations of These Data between 48 Hours and 12 Weeks
| Parameter | LAD occlusion (n = 20) | Sham operation (n = 9) | P value |
|---|---|---|---|
| 48-h pinhole SPECT | |||
| Necrotic myocardium (% LV) | 14 ± 14 | 0 ± 0 | 0.004 |
| End-diastolic volume (μL) | 320 ± 84 | 293 ± 48 | NS |
| End-systolic volume (μL) | 146 ± 71 | 113 ± 10 | NS |
| Ejection fraction (%) | 56 ± 12 | 61 ± 4 | NS |
| 12-wk pinhole SPECT | |||
| Necrotic myocardium (% LV) | 16 ± 16 | 0 ± 0 | 0.004 |
| End-diastolic volume (μL) | 501 ± 191 | 343 ± 46 | 0.01 |
| End-systolic volume (μL) | 294 ± 183 | 154 ± 24 | 0.03 |
| Ejection fraction (%) | 46 ± 13 | 55 ± 5 | 0.05 |
| Absolute variations between 48 h and 12 wk | |||
| Necrotic myocardium (% LV) | 2 ± 3 | 0 ± 0 | NS |
| End-diastolic volume (μL) | 182 ± 149 | 50 ± 15 | 0.002 |
| End-systolic volume (μL) | 148 ± 133 | 40 ± 17 | 0.01 |
| Ejection fraction (%) | −10 ± 9 | −5 ± 6 | NS |
LAD = left anterior descending coronary artery; LV = left ventricle; NS = nonsignificant.