Characteristic | Healthy subjects (MRI, n = 54/PET, n = 30) | Presymptomatic HD (n = 24) | Symptomatic HD (n = 47) |
---|---|---|---|
Mean age ± SD (y) | 36.8 ± 13.9/35.4 ± 12.6 | 35.8 ± 9.2 | 46.3 ± 10.7 |
Mean age at onset ± SD (y) | NA | NA | 38.6 ± 11.36 |
Age range at onset (y) | NA | 18–60 | |
Mean UHDRS motor score ± SD | NA | 4.2 ± 3.5 | 45.8 ± 20.3 |
Male-to-female ratio | 26:28/14:16 | 16:7 | 26:20 |
Mean repeat length ± SD | NA | 43.5 ± 3.2 | 46.5 ± 5.5 |
Range of repeat length | NA | 39–50 | 39–70 |
Right-handedness (%) | 98.3/99.2 | 99.1 | 98.8 |
No. of patients followed up | NA | 10 | 21 |
Mean follow-up interval ± SD (mo) | NA | 16.2 ± 3.3 | 18.4 ± 4.2 |
Range of follow-up interval (mo) | NA | 12–24 | 12–27 |
NA = not applicable.
As control population, 2 cohorts of healthy subjects underwent MRI and 18F-FDG PET for comparison with HD subjects.