Lesion-Based Analysis of 112 Lesions with Increased 18F-Fluoride for Which SPECT Was Available
| Final diagnosis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metastases (n = 41) | No metastases (n = 71) | Interpretation* | ||||||||
| Modality | M | E | B/N | M | E | B/N | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Planar BS | 10 | 6 | 25 | 2 | 13 | 56 | 39 (24) | 79 (97) | 52 (83) | 64 (69) |
| SPECT | 10 | 19 | 12 | 3 | 8 | 60 | 71 (24) | 85 (96) | 73 (77) | 83 (69) |
| 18F-Fluoride PET | 14 | 27 | 0 | 2 | 8 | 61 | 100 (34) | 86 (96) | 80 (88) | 100 (72) |
| 18F-Fluoride PET/CT | 32 | 9 | 0 | 0 | 0 | 71 | 100 (78) | 100 (100) | 100 (100) | 100 (89) |
↵* In results analysis, normal and benign interpretation was considered nonmalignant. Equivocal and malignant interpretation was considered malignant. In parentheses, results analysis with normal, benign, and equivocal interpretation being considered nonmalignant. M = malignant; E = equivocal; B/N = benign or normal.