Assessment of Skeletal Metastatic Spread by Planar 99mTc-MDP BS, Planar and SPECT BS, 18F-Fluoride PET, and 18F-Fluoride PET/CT: Lesion-Based Analysis of 156 Lesions
| Final diagnosis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metastases (n = 57) | No metastases (n = 99) | Interpretation* | ||||||||
| Modality | M | E | B/N | M | E | B/N | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Planar BS | 13 | 9 | 35 | 2 | 15 | 82 | 39 (23) | 83 (98) | 56 (87) | 70 (69) |
| Planar and SPECT† | 12 | 23 | 22 | 3 | 10 | 86 | 61 (21) | 87 (97) | 73 (80) | 80 (81) |
| 18F-Fluoride PET | 19 | 38 | 0 | 3 | 18 | 78 | 100 (33) | 79 (96) | 73 (86) | 100 (100) |
| 18F-Fluoride PET/CT | 46 | 11 | 0 | 0 | 0 | 99 | 100 (81) | 100 (100) | 100 (100) | 100 (90) |
↵* In results analysis, normal and benign interpretation was considered nonmalignant. Equivocal and malignant interpretation was considered malignant. In parentheses, results analysis with normal, benign, and equivocal interpretation being considered nonmalignant.
↵† Planar and SPECT interpretation of 112 lesions and planar interpretation alone for the remaining 44 lesions, which were not included in SPECT FOV.
M = malignant; E = equivocal; B/N = benign or normal.