Assessment of Skeletal Metastatic Spread by Planar 99mTc-MDP BS, Planar and SPECT BS, 18F-Fluoride PET, and 18F-Fluoride PET/CT: Patient-Based Analysis in 44 Patients with High-Risk Prostate Cancer
| Final diagnosis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Spread of metastases (n = 23) | No metastases (n = 11) | Interpretation* | ||||||||
| Modality | M | E | B/N | M | E | B/N | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Planar BS | 8 | 5 | 10 | 1 | 8 | 12 | 57 (35) | 57 (95) | 59 (89) | 55 (44) |
| Planar + SPECT† | 9 | 9 | 5 | 3 | 4 | 14 | 78 (39) | 67 (86) | 72 (75) | 74 (31) |
| 18F-Fluoride PET | 11 | 12 | 0 | 1 | 7 | 13 | 100 (48) | 62 (95) | 74 (92) | 100 (63) |
| 18F-Fluoride PET/CT | 20 | 3 | 0 | 0 | 0 | 21 | 100 (87) | 100 (100) | 100 (100) | 100 (87) |
↵* Analysis considering equivocal reading as positive for malignancy. In parentheses, analysis considering equivocal results as negative for malignancy.
↵† 99mTc-MDP BS including planar and a single-FOV SPECT in 20 patients and planar and multi-FOV SPECT in 24 patients.
M = malignant; E = equivocal; B/N = benign or normal.