TABLE 3

Mean Percentage Changes in ¹⁸F-FDG Uptake in Asymptomatic and Symptomatic HD Subjects

		Asymptomatic HD subjects		Symptomatic HD subjects
Brain region	Side	¹⁸F-FDG decrease (%)	P	¹⁸F-FDG decrease (%)	P
Caudate	L	−23.10	0.0044^*	−34.56	0.0000^*
	R	−26.53	0.0001^*	−34.39	0.0000^*
Putamen	L	−14.85	0.0003^*	−16.67	0.0015^*
	R	−13.90	0.0269	−19.75	0.0058^*
Frontal	L	−9.52	0.0144	−8.56	0.0256
	R	−11.86	0.0037^*	−8.57	0.0049^*
Temporal	L	−6.43	0.0271	−3.74	0.2199
	R	−8.05	0.0073	−4.61	0.0494
Parietal	L	−2.94	NS	−0.97	NS
	R	−4.70	NS	−2.26	NS

↵* Significant after corrections for multiple comparisons.
NS = not significant.
Significant differences from healthy subjects were found in striatum (caudate and putamen) and in frontotemporal cortex of asymptomatic and symptomatic subjects.