Effect of Various Simulated Noises and Start Time (t*) on BP or DV Estimated by NLS, Logan Plot, and MA
| Bias: noise | COV: noise | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Method | Parameter | 0% | 1% | 3% | 5% | 7% | 10% | 0% | 1% | 3% | 5% | 7% | 10% |
| NLS | BP | 0 | 0.100 | 0.785 | 2.43 | 5.07 | 11.3 | 0 | 2.03 | 5.81 | 10.4 | 15.6 | 26.7 |
| DV | 0 | 0.100 | 0.785 | 2.43 | 5.07 | 11.3 | 0 | 2.03 | 5.81 | 10.4 | 15.6 | 26.7 | |
| 0 | 0.109 | 0.685 | 2.03 | 4.25 | 7.66 | 0 | 1.92 | 5.60 | 10.4 | 16.7 | 25.9 | ||
| Logan plot | DV (t* = 30) | −16.6 | −16.7 | −17.7 | −19.7 | −22.2 | −27.1 | 0 | 0.797 | 2.20 | 3.63 | 4.81 | 6.51 |
| DV (t* = 40) | −12.4 | −12.6 | −14.0 | −16.9 | −20.6 | −27.2 | 0 | 1.12 | 3.04 | 4.88 | 6.25 | 8.05 | |
| DV (t* = 50) | −10.5 | −10.7 | −12.6 | −16.4 | −21.0 | −28.9 | 0 | 1.38 | 3.71 | 5.82 | 7.33 | 9.34 | |
| DV (t* = 60) | −8.53 | −8.96 | −11.7 | −17.2 | −23.1 | −32.4 | 0 | 1.77 | 4.64 | 7.00 | 8.49 | 10.8 | |
| MA | DV (t* = 30) | −16.0 | −16.0 | −15.9 | −15.7 | −15.5 | −15.0 | 0 | 0.850 | 2.40 | 4.13 | 5.72 | 8.35 |
| DV (t* = 40) | −12.3 | −12.2 | −12.0 | −11.6 | −11.0 | −9.91 | 0 | 1.16 | 3.28 | 5.72 | 8.07 | 12.3 | |
| DV (t* = 50) | −10.4 | −10.4 | −10.1 | −9.55 | −8.83 | −7.09 | 0 | 1.41 | 4.02 | 7.08 | 10.1 | 16.3 | |
| DV (t* = 60) | −8.53 | −8.49 | −8.14 | −7.33 | −6.11 | −3.58 | 0 | 1.81 | 5.20 | 9.41 | 14.4 | 22.0 | |
NLS = nonlinear least squares; GA = graphical analysis; MA = multilinear analysis; DV = distribution volume.
Bias and COV are expressed as a percentile normalized by true value.