TABLE 1

Previous SPECT and PET In Vivo Studies on the Age Dependence of SERT Availability in Humans

		Subjects			Correlation of SERT availability and age (linear regression analysis)
Reference	Tracer	Condition	n	Age (y)	Region	r	P	Change (% per decade)
3	¹¹C-(+)McN5652	Healthy	28	20−79	Thalamus	−0.64	<0.0003	−9.6
					Midbrain	−0.54	<0.03	−10.5
4	¹²³I-ADAM	Healthy	6	24−56	Midbrain	−0.98	0.0002	−3.0
5	¹²³I-nor-β-CIT	Healthy	19	22−74	Midbrain	−0.47	<0.05	−2
6	¹²³I-β-CIT	Healthy	30	21−71	Thalamus/hypothalamus	−0.512	0.004	−3.2
					Midbrain/pons	−0.449	0.013	−4.5
7	¹²³I-β-CIT	Healthy	126	18−88	Brain stem	−0.40	<0.0001	−4.2
8	¹²³I-β-CIT	Healthy	22	18−83	Thalamus/hypothalamus	−0.80	<0.001	−7.2
					Midbrain/upper brain stem	−0.74	<0.001	−8.3
9	¹²³I-β-CIT	Healthy	23	24−77	Brain stem		NS
					Cortex		NS
10	¹²³I-β-CIT	Alcoholic (n = 22) + healthy (n = 13)	35	22−55	Dorsal brain stem	−0.06	0.75
11	¹²³I-β-CIT	Depressive	41	7−17	Hypothalamus/midbrain		NS