In Vitro Cell Binding and Internalization (Percentage of Total Added Radioactivity) of Radiotracer 99mTc-PAMA-Folate in Cultured KB Cells Pretreated with MTX, RTX, PMX, and LV*
| MTX | RTX | PMX | LV | |||||
|---|---|---|---|---|---|---|---|---|
| Dose | Total binding | Internalization | Total binding | Internalization | Total binding | Internalization | Total binding | Internalization |
| Control | 31.8 ± 7.0 | 4.5 ± 0.9 | 25.7 ± 0.6 | 7.8 ± 0.5 | 34.6 ± 1.4 | 10.2 ± 1.2 | 33.1 ± 1.4 | 6.8 ± 0.8 |
| 0.1 μmol/L | 42.1 ± 12.8 | 10.8 ± 0.1 | 35.3 ± 3.6 | 12.1 ± 1.0 | 55.1 ± 9.8 | 17.6 ± 1.6 | 34.8 ± 5.1 | 8.7 ± 0.7 |
| 1.0 μmol/L | 68.0 ± 8.7 | 13.1 ± 1.3 | 48.5 ± 8.0 | 14.0 ± 1.9 | 66.9 ± 2.3 | 15.7 ± 1.0 | 29.8 ± 1.4 | 5.9 ± 0.8 |
| 10 μmol/L | 77.3 ± 5.7 | 18.8 ± 1.8 | 64.5 ± 3.5 | 19.0 ± 2.2 | 78.8 ± 10.7 | 26.7 ± 4.7 | 15.8 ± 0.9 | 4.3 ± 0.4 |
↵* n = 3. Data are reported as mean ± SD percentages.