Biodistribution (%ID/g ± SD, n = 5) at 1, 4, and 24 Hours of [64Cu-EPH144]+ and [64Cu-EPH270]+ in CFD1 Mice Bearing Lymphocytic Leukemia L1210 Tumors
| Time (h) | |||
|---|---|---|---|
| Biodistribution | 1 | 4 | 24 |
| [64Cu-EPH144]+ | |||
| Blood | 5.03 ± 0.46 | 4.04 ± 0.41 | 2.58 ± 0.43 |
| Lung | 24.36 ± 7.60 | 20.38 ± 5.53 | 14.49 ± 2.89 |
| Liver | 39.95 ± 7.06 | 34.57 ± 8.01 | 22.11 ± 5.16 |
| Spleen | 15.02 ± 3.30 | 11.75 ± 1.46 | 8.42 ± 1.17 |
| Kidney | 24.32 ± 2.73 | 15.79 ± 1.84 | 12.92 ± 2.98 |
| Muscle | 2.06 ± 0.48 | 1.60 ± 0.41 | 1.34 ± 0.30 |
| Fat | 1.38 ± 0.33 | 1.01 ± 0.40 | 0.62 ± 0.24 |
| Heart | 14.29 ± 1.70 | 11.66 ± 2.35 | 9.87 ± 2.21 |
| Bone | 2.71 ± 0.58 | 2.66 ± 0.40 | 2.50 ± 1.16 |
| Tumor | 4.70 ± 0.47 | 8.80 ± 1.94 | 6.64 ± 1.30 |
| [64Cu-EPH270]+ | |||
| Blood | 3.69 ± 1.69 | 5.14 ± 1.20 | 3.05 ± 0.58 |
| Lung | 19.40 ± 14.20 | 27.14 ± 6.02 | 14.87 ± 4.03 |
| Liver | 20.15 ± 11.90 | 28.01 ± 5.57 | 18.41 ± 4.45 |
| Spleen | 6.17 ± 4.10 | 10.46 ± 2.90 | 6.53 ± 2.13 |
| Kidney | 16.45 ± 6.06 | 14.35 ± 5.62 | 11.10 ± 1.95 |
| Muscle | 1.01 ± 0.54 | 1.11 ± 0.28 | 1.06 ± 0.25 |
| Fat | 0.61 ± 0.26 | 1.11 ± 0.48 | 0.38 ± 0.34 |
| Heart | 5.23 ± 3.27 | 9.08 ± 1.63 | 7.43 ± 1.74 |
| Bone | 2.91 ± 3.97 | 1.94 ± 0.76 | 1.52 ± 0.56 |
| Tumor | 2.58 ± 1.42 | 6.00 ± 0.75 | 4.80 ± 0.89 |