TABLE 3

Treatment-Related Toxicities

Patient no.Chemotherapy/ 186Re-HEDP interval (mo)186Re-HEDP/EBRT interval (wk)Platelet nadir gradeWhite blood cell nadir gradeWHO status* at 186Re-HEDP therapyOther toxicity
163001Preexisting chronic renal failure; no change after 186Re-HEDP therapy
263003None
322241Initial toxicity after first course only; white blood cell grade 4 toxicity after 4 cycles; patient recovered but was unable to tolerate palliative chemotherapy
421.6312Completely resolved at 4 mo
5832 on second dose21None
61.514 during EBRT32Platelet toxicity persisted at grade 4 for 4 wk and required transfusion; gradually rose but never much beyond 50 × 109/L
71.752001None
8361001None
94002None
10143012None
113.55012Died within 4 wk because of pulmonary infection (unspecified)
1252001None
1376031None
  • * Criteria of the World Health Organization (11).