TABLE 1

Biodistribution and Tissue Radioactivity Ratio in Tumor-Bearing Rip1Tag2 Mice at 4, 24, and 48 Hours After Injection of 2 pmol [Lys40(Ahx-DTPA-111In)NH2]Exendin-4

[Lys40(Ahx-DTPA-111In)NH2]exendin-4
OrganTime (h)Nonblocked (%IA/g)Blocked* (%IA/g)
Lung465.08 ± 18.620.86 ± 0.04
2451.58 ± 4.25
4831.21 ± 2.73
Pancreas421.13 ± 7.351.44 ± 0.43
2420.05 ± 4.29
4813.59 ± 0.47
Stomach44.68 ± 0.730.72 ± 0.23
242.86 ± 0.25
482.75 ± 0.53
Tumor4287.37 ± 62.377.28 ± 3.50
24181.82 ± 81.77
48132.01 ± 41.04
Kidneys4208.77 ± 34.68214.91 ± 4.71
24148.16 ± 35.98
48104.10 ± 15.04
Liver40.97 ± 0.270.35 ± 0.09
240.68 ± 0.10
480.53 ± 0.07
Spleen41.55 ± 0.731.77 ± 0.31
241.18 ± 0.16
480.91 ± 0.14
Bone40.40 ± 0.130.07 ± 0.04
240.30 ± 0.08
480.42 ± 0.19
Blood40.29 ± 0.220.16 ± 0.03
240.10 ± 0.01
480.06 ± 0.01
[Lys40(Ahx-DTPA-111In)NH2]exendin-4
Ratio4 h after injection48 h after injection
Tumor/blood9912,200
Tumor/kidneys1.381.27
Tumor/lung4.424.23
Tumor/pancreas13.69.71
  • * Blocked with 2 nmol [Lys40(Ahx-DTPA-natIn)NH2]exendin-4.

  • GLP-1 receptor–positive organs.

  • Values are given as %IA/g tissue ± SD.