Biodistribution of 125I-Labeled mAb 11-1F4 in Normal BALB/c Mice
| Mean ± SD %ID/g at: | |||||
|---|---|---|---|---|---|
| Tissue | 1 h | 4 h | 24 h | 72 h | 144 h |
| Blood | 42.5 ± 6.0 | 32.6 ± 2.2 | 26.8 ± 1.0 | 18.4 ± 2.3 | 16.7 ± 1.0 |
| Skin | 1.1 ± 0.3 | 2.3 ± 0.3 | 3.1 ± 0.3 | 2.6 ± 0.2 | 2.1 ± 0.2 |
| Muscle | 1.3 ± 0.2 | 2.4 ± 0.9 | 2.1 ± 0.2 | 1.7 ± 0.3 | 1.4 ± 0.1 |
| Femur | 2.4 ± 0.2 | 3.0 ± 0.6 | 2.8 ± 2.2 | 2.2 ± 0.5 | 1.9 ± 0.3 |
| Fat pad | 0.8 ± 0.1 | 2.5 ± 0.7 | 1.9 ± 1.3 | 1.3 ± 0.2 | 1.5 ± 0.2 |
| Liver | 14.0 ± 0.3 | 11.4 ± 0.7 | 8.6 ± 5.7 | 5.7 ± 1.0 | 5.6 ± 0.5 |
| Spleen | 11.7 ± 1.2 | 10.0 ± 1.1 | 8.1 ± 0.6 | 5.2 ± 0.9 | 4.6 ± 0.7 |
| Pancreas | 2.4 ± 0.5 | 2.8 ± 0.5 | 2.7 ± 0.4 | 1.9 ± 0.2 | 1.7 ± 0.3 |
| Stomach | 2.5 ± 0.4 | 4.0 ± 0.4 | 3.1 ± 0.3 | 2.2 ± 0.1 | 1.7 ± 0.2 |
| Small intestine | 4.1 ± 0.5 | 4.5 ± 0.5 | 3.2 ± 0.2 | 2.4 ± 0.3 | 2.1 ± 0.2 |
| Cecum | 2.5 ± 0.5 | 5.9 ± 0.4 | 4.3 ± 0.6 | 3.0 ± 0.4 | 2.2 ± 0.3 |
| Large intestine | 2.2 ± 0.3 | 4.1 ± 0.5 | 3.6 ± 0.2 | 2.5 ± 0.4 | 1.9 ± 0.2 |
| Kidney (L) | 7.8 ± 1.1 | 7.8 ± 1.9 | 5.4 ± 0.6 | 4.1 ± 0.8 | 3.4 ± 0.6 |
| Kidney (R) | 8.0 ± 1.2 | 8.2 ± 1.4 | 5.7 ± 0.7 | 4.3 ± 0.7 | 3.4 ± 0.5 |
| Throat* | 4.8 ± 1.2 | 9.0 ± 2.0 | 6.4 ± 1.6 | 4.5 ± 0.7 | 4.3 ± 0.9 |
| Heart | 12.6 ± 2.4 | 10.1 ± 1.4 | 9.5 ± 2.1 | 6.4 ± 1.5 | 5.4 ± 0.6 |
| Lungs | 13.8 ± 1.4 | 13.3 ± 1.9 | 10.5 ± 0.7 | 7.2 ± 3.4 | 6.8 ± 0.6 |
| Tongue | 3.4 ± 1.3 | 8.0 ± 0.9 | 7.2 ± 0.7 | 8.8 ± 7.7 | 4.4 ± 0.4 |
| Brain | 0.9 ± 0.2 | 0.8 ± 0.1 | 0.6 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.1 |
↵* Tissue includes esophagus and thyroid gland (n = 6).