Subjects' Characteristics
| Characteristic | Control subjects (n = 7) | FAD subjects | ||||||
|---|---|---|---|---|---|---|---|---|
| Subject no. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
| Age (y) | 43 (5) | 35 | 40 | 41 | 42 | 45 | 47 | 49 |
| Sex (M/F) | 3/4 | F | M | M | F | F | F | M |
| Education (y) | 15 (1) | 16 | 14 | 16 | 16 | 14 | 14 | 16 |
| PS-1 mutation | — | Cys92Ser | Leu392Val | Met146Leu | Cys92Ser | Leu392Val | Leu392Val | Cys92Ser |
| ApoE | 5 e3/e3; 2 e3/e4 | e3/e3 | e3/e4 | e3/e3 | e3/e3 | e3/e4 | e3/e3 | e3/e3 |
| MMSE | 30 | 30 | 30 | 30 | 30 | 27 | 25 | 30 |
| Token test | 35.7 (0.5) | 35 | 36 | 32 | 36 | 36 | 34 | 33 |
| Designs test | 16 (0.5) | 16 | 16 | 11 | 16 | 16 | 16 | 14 |
| Rey's complex figure | ||||||||
| Copy | 36 (1) | 32 | 36 | 22 | 30 | 36 | 36 | 36 |
| Recall | 25 (2) | 24 | 14 | 11 | 12 | 7 | 6 | 7 |
| Paired associates, delayed recall | 22 (2) | 24 | 24 | 1 | 21 | 15 | 14 | 20 |
| Trail making test, part B (s) | 88 (13) | 90 | 89 | 129 | 78 | 63 | 63 | 54 |
| Stroop test (interference, s) | 32 (6) | 30 | 32 | 17 | 24 | 22 | 27 | 30 |
| Phonemic fluency test | 42 (6) | 36 | 36 | 25 | 43 | 32 | 37 | 29 |
Values for control group are means (SD). FAD subjects are ordered by age.