VMAT2 Transporter Densities in Brain
| 11C-DTBZ binding potential in* | ||||
|---|---|---|---|---|
| Group (n) | Caudate nucleus | Anterior putamen | Posterior putamen | AP gradient† |
| Control (10) | 2.09 ± 0.25 | 2.48 ± 0.29 | 2.52 ± 0.32 | 0.83 ± 0.06 |
| IPD (9) | 1.30 ± 0.45 (63) [0.0010] | 0.94 ± 0.32 (38) [4.3 × 10−8] | 0.60 ± 0.14 (24) [1.8 × 10−10] | 2.22 ± 0.69 [3.5 × 10−9] |
| MSA (10) | 1.31 ± 0.75 (63) [0.0052] | 1.30 ± 0.79 (53) [4.9 × 10−4] | 1.26 ± 0.83 (50) [4.3 × 10−4] | 1.13 ± 0.25 [0.0011] |
| PSP (8) | 0.95 ± 0.38 (46) [5.8 × 10−6] | 0.92 ± 0.48 (37) [2.9 × 10−6] | 0.85 ± 0.53 (34) [3.9 × 10−6] | 1.23 ± 0.35 [9.9 × 10−4] |
↵* For 11C-DTBZ binding potentials, data shown are mean ± SD, percentage of normal mean in parentheses, and P value for single-tailed Student t test, assuming unequal variances between each patient group and healthy control group, in brackets.
↵† AP gradient = ratio of 11C-DTBZ binding potentials in caudate nucleus and posterior putamen, calculated individually for each subject.